Released in 2003, Crestor was being marketed by AstraZeneca with claims that the drug can lower up to 52% of cholesterol levels. Crestor carries the generic name of rosuvastatin, and belongs in the HMG CoA reductase inhibitor group of drugs called statins.
Similar to the drugs belonging in this group, Crestor reduces levels of triglycerides and bad cholesterol, called low-density lipoprotein, in the blood all whilst increasing the good cholesterol levels called high-density lipoprotein.
By increasing the high-density lipoproteins and decreasing the low-density lipoproteins, individuals are able to prevent high costs of heart surgery and reduce heart attack and stroke occurrences in patients. Crestor slows down the cholesterol breakdown by preventing HMG CoA reductase enzyme production in the liver. Crestor then slows the progression of blocked arteries as well as lowering triglyceride levels.
Crestor is prescribed usually to men over 50 years old and to women over 60 years old with elevated high-sensitivity C-reactive protein levels that indicate inflammation. It is also being prescribed for patients with cardiovascular risk factors like high blood pressure, a family history of heart disease, smoking or low HDLs. Blood tests may be used to measure the amount of cholesterol in the blood to determine if Crestor treatment is necessary for the patients.
It was initially approved for use in patients with bad cholesterol and a history of heart disease. It was in 2010, 7 years after its first approval, when Crestor was approved for the use of heart attack, strokes and death prevention in people who have elevated C-reactive protein levels. The drug is also used to lower the risk of stroke, heart attack, and other heart conditions in individuals with diabetes, and coronary heart disease, among others. Crestor is prescribed to children and adults with at least 10 years of age.
Statins are a very well known drug class of cholesterol lowering drugs; with Crestor taking the number two spot of highest sales in the category, after Lipitor. A survey showed that 22% of Americans over the age of 45 take some kind of statin. Statins, which have existed since the late 1980s, thus, rake in profits worth more than $20 billion per year. Crestor has reached global sales with $6.6 billion on 2011.
Strokes and coronary artery diseases are to blame in one of every three deaths in the United States. Statins have been the go-to drug to treat these problems in individuals who have difficulty maintaining a healthier lifestyle. All statins, including Crestor, control cholesterol by controlling the enzyme production in the liver that is naturally responsible for cholesterol production.Scroll to Top